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Tinatin Chabrashvili, MD, PhD accepting new patients


Programs + Specialties
Research Interests Neurovascular mechanisms of neurodegeneration, cerebrovascular biology, vascular inflammation, blood-brain barrier, regulation of the cerebral blood flows, adult neurogenesis neuroprotection and neurorepair after stroke
Training + Education The Tbilisi State Medical University, Georgia; Institute of Neurology, Russian Academy of Medical Sciences, Moscow; Emory University School of Medicine; NINDS, NIH, Bethesda
Board Certifications Neurology
NPI # 1235316662
Gender Female
Language(s) Russian, Georgian

Locations + Directions

Tufts Medical Center
800 Washington St.
Box 314
Boston, MA 02111
Fax #: 617-636-8199
Phone #: 617-636-8015

Honors + Awards

Gold Medal for Excellence, Educational Ministry of Georgia
The Fogarty International Fellowship, NINDS/NIH, Bethesda, MD
The 6th Annual AstraZeneca Young Cardiovascular Investigator Meeting, Quebec, Canada
The Sellie Mae Young Investigator Award, National Kidney Foundation

Publications + National Presentations

1. Bagashev A, Fan S, Mukerjee R, Claudio PP, Chabrashvili T, Leng RP, Benchimol S, Sawaya BE. Cdk9 phosphorylates Pirh2 protein and prevents degradation of p53 protein. Cell Cycle. 2013; 12(10): 1569-77.

2. Chang JR, Ghafouri M, Mukerjee R, Chabrashvili T, Sawaya BE. Role of p53 in neurodegeneration. Neurodegener Dis. 2012;9(2):68-80.

3. Chang JR, Mukerjee R, Del Valle L, Bagashev A, Hawkins BJ, Chabrashvili T, Sawaya BE. HIV-1 Tat promotes neuronal dysfunction through disruption of microRNAs. J Biol Chem, 2011;286(47):41125-34.

4. Zhang, M, Mao M, Ramirez SH, Tuma, R., Chabrashvili, T. (senior corresponding author). Angiotensin II Induced Cerebral Microvascular Inflammation and Increased Blood-Brain Barrier Permeability via oxidative stress: Neuroscience: 2010, 171(3):852-8.

5. Wang, D.*, Gill, P*. Chabrashvili, T.*, Onozato ML, Raggio, J , Mendonca, M., Dennehy, K, Li, M., Modlinger, M., Leiper, J., Vallance, P., Adler, O., Leone, A.’ Tojo, A., Welch, WJ., Wilcox, CS. Isoform-Specific Regulation by NG,NG-Dimethylarginine Dimethylaminohydrolase of Rat Serum Asymmetric Dimethylarginine and Vascular Endothelium-Derived Relaxing Factor/NO. Circulation Research. 2007; 101:627-35. (* These authors contributed equally to this study).

6. Welch, W. J., Chabrashvili, T. Solis, G, Gill, P., Chen, Y., Wang, S., Ji, H., Sandberg, K. , Jose, P., and Wilcox C. S. Role of extracellular superoxide dismutase in the mouse angiotensin slow pressor response. Hypertension. 2006; 48 (5): 934-41.

7. Modlinger, P*, Chabrashvili, T*, Gill, P.S.*, Mendonca, M., Harrison, D., Raggio, J., Wellstein, A., Chen, Y., Welch, W.J., Wilcox, C.S. RNA silencing in vivo reveals role of p22phox in rat angiotensin slow pressor response. Hypertension. 2006; 47 (2): 238-44. (* These authors contributed equally to this study).

8. Wang, D, Chabrashvilli, T, Borrego, L, Aslam, S, Umans, J. Angiotensin II Infusion Alters Vascular Function in Mouse Resistance Vessels: Roles of O2- and Endothelium. Journal of Vascular Research J Vasc Res 2006;43:109-119.

9. Welch WJ, Blau J, Xie H, Chabrashvili T, Wilcox CS. Angiotensin-induced defects in renal oxygenation: role of oxidative stress. Am J Physiol Heart Circ Physiol. 2005; 88(1): H22-8.

10. Dan Wang, Tina Chabrashvili, and Christopher S. Wilcox. Independent roles of oxidative stress and TP receptors in endothelial dysfunction and contractions to angiotensin II of afferent arterioles from Ang II-infused rabbits. Circulation Research. 2004: 11;94(11):1436-42.

11. Dan Wang, Yifan Chen, Tina Chabrashvili, Shakil Aslam, Lillian Borrego, Jason Umans, Christopher S. Wilcox. Role of oxidative stress in endothelial dysfunction and enhanced responses to Ang II of afferent arterioles from rabbits infused with Ang II. J. Am. Soc. Nephrol 2003; 14(11): 2783-9.

12. Chagriya Kitiyakara*, Tina Chabrashvili*, Jonathan Blau, Alex Karber, Shakil Aslam, William J. Welch, Christopher S. Wilcox. Salt intake, nitric oxide, oxidative stress and renal expression of NADPH oxidase and SOD. J. Am. Soc. Nephrol 2003; 14(11): 2775-82. *These authors contributed equally to the paper

13. Tina Chabrashvili, Chagriya Kitiyakara, Jonathan Blau, Alex Karber, Shakil Aslam, William J. Welch, and Christopher S. Wilcox. Effects of Ang II type I and type II receptors on oxidative stress and renal NADPH oxidase and SOD expression. AJP - Regulatory, Integrative and Comparative Physiology. 2003; 285(1): R117-24.

Professional Memberships

American Heart Association - Stroke Council and Council for High Blood Pressure Research
American Academy of Neurology
Movement Disorders Society
International Society for Cerebral Blood Flow and Metabolism

News, Media + Videos

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