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Jennifer DuPont, PhD


Training + Education University of Delaware
Gender Female
Accepted Insurances View Accepted Insurances at Tufts MC + Floating Hospital

Honors + Awards

June 2016, Natalie V. Zucker Research Center for Women Scholars Award, Tufts Medical Center
March 2016, Young Investigator Award Finalist, International Aldosterone Conference
April 2015, Cardiovascular Section Research Recognition Award, American Physiological Society
April 2015, Caroline tum Suden Professional Opportunity Award, American Physiological Society
2014-2016, American Heart Association Postdoctoral Fellowship, American Heart Association
April 2013, Caroline tum Suden Professional Opportunity Award, American Physiological Society

Publications + National Presentations

DuPont JJ, McCurley A, Davel AP, McCarthy J, Bender SB, Hong K, Yang Y, Yoo J, Aronovitz MA, Baur WE, Christou DD, Hill MA, Jaffe IZ. Smooth muscle cell mineralocorticoid receptor regulation of vascular microRNA-155 contributes to vascular dysfunction and rising blood pressure with aging. Journal of Clinical Investigation Insight. 2016, 1(14):e88942.

Burke SD, Zsengeller ZK, Khankin EV, Agnes S. Lo AS, Rajakumar A, DuPont JJ, McCurley A, Moss ME, Zhang D, Clark CD, Wang A, Seely EW, Kang PM, Stillman IE, Jaffe IZ, Karumanchi SA. Soluble fms-like tyrosine kinase 1 promotes angiotensin II sensitivity during preeclampsia by impairing endothelial nitric oxide function. Journal of Clinical Investigation. 2016, 126(7):2561-74.

DuPont JJ, Ramick MG, Farquhar WB, Townsend RR, Edwards DG. NADPH oxidase-derived reactive oxygen species contribute to impaired cutaneous microvascular function in chronic kidney disease. Am J Physiol Renal Physiol. 2014, 306(12):F1499-506.

DuPont JJ, Hill MA, Bender SB, Jaisser F, Jaffe IZ. Aldosterone and mineralocorticoid receptors: Regulators of ion channels beyond the kidney. Hypertension. 2014, 63(4):632-7.

DuPont JJ, Greaney JL, Wenner MM, Lennon-Edwards SL, Sanders PW, Farquhar WB, and Edwards DG. High dietary sodium intake impairs endothelium-dependent dilation in healthy salt-resistant humans. J Hypertens. 2013, 31(3):530-6.

Greaney JL, DuPont JJ, Lennon-Edwards SL, Sanders PW, Farquhar WB, Edwards DG. Dietary sodium loading impairs microvascular function independent of blood pressure in humans: role of oxidative stress. J Physiol. 2012, 590(21): 5519-28.

DuPont JJ, Farquhar WB, Townsend RR, Edwards DG. Ascorbic acid or L-arginine improves cutaneous microvascular function in chronic kidney disease. J Appl Physiol. 2011, 111(6):1561-7.

DuPont JJ, Farquhar WB, Edwards DG. Intradermal microdialysis of hypertonic saline attenuates cutaneous vasodilation in response to local heating. Exp Physiol. 2011, 96(7):674-80.

Kuczmarski JM, Darocki MD, DuPont JJ, Sikes RA, Cooper CR, Farquhar WB, Edwards DG. The effect of moderate-to-severe chronic kidney disease on flow mediated dilation and progenitor cells. Exp. Biol. Med. 2011, 236(9):1085-92


Jennifer received her M.S. in Exercise Physiology and Ph.D. in Applied Physiology from the University of Delaware. Her graduate research was focused on mechanisms of microvascular dysfunction in chronic kidney disease patients as well as the effects of dietary sodium on vascular function. She joined the MCRI in June 2013 and is currently a postdoctoral fellow in the laboratory of Dr. Iris Z. Jaffe, where her research is focused on the role of the smooth muscle cell mineralocorticoid receptor (SMC-MR) in vascular aging. Specifically, she is investigating the role of SMC-MR in the regulation of aging-associated hypertension and sex differences in the molecular mechanisms of vascular aging.

Professional Memberships

American Physiological Society
American Heart Association
Endocrine Society