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CardioVascular Center

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Gordon S. Huggins, MD accepting new patients


Training + Education University of Chicago, Pritzker School of Medicine; Massachusetts General Hospital
Board Certifications Internal Medicine, Cardiovascular Disease
NPI # 1255345559
Gender Male

Locations + Directions

Tufts Medical Center
South Building, 6th Floor
800 Washington St.
Box 8486
Boston, MA 02111
Fax #: 617-636-5649
Phone #: 617-636-2273

Honors + Awards

1986, Distinguished Undergraduate Research Award
1987, Viets Research Fellowship, Myasthenia Gravis Foundation
1989, Calvin Fentress Research Fellowship
1990, Leon Jacobson Prize for Distinguished Basic Science Research
1994, Stanford Calderwood Manuscript Prize
1999, Second Place, American College of Cardiology Young Investigator Competition

Publications + National Presentations

Peter I, Hedgepeth AK, Huggins GS, Housman DE, Mendelsohn ME, Vita JA, Vasan RS, Levy D, Benjamin EJ, Mitchell GM. Association between arterial stiffness and variations in estrogen-related genes. Journal of Human Hypertension 2009;2009 Feb 5. [Epub ahead of print]

Kelley-Hedgepeth A, Peter I, Montefusco MC, Levy D, Benjamin EJ, Vasan RS, Mendelsohn ME, Housman D, Huggins GS, Mitchell GF. The KCNMB1 E65K variant is associated with reduced central pulse pressure in the community-based Framingham Offspring Cohort. Journal of Hypertension 2009;27(1):55-60.

Kerkela R, Kockeritz L, Macaulay K, Zhou J, Doble BW, Beahm C, Greytak S, Woulfe K, Trivedi CM, Woodgett JR, Epstein JA, Force T, Huggins GS. Deletion of GSK-3β in Mice Leads to Hypertrophic Cardiomyopathy Secondary to Cardiomyoblast Hyperproliferation. Journal of Clinical Investigation 2008;118(11):3609-3618.

Rouf R, Greytak S, Wooten EC, Wu J, Boltax J, Picard M, Svensson EC, Dillmann WH, Patten RD, Huggins GS. Increased FOG-2 in failing myocardium disrupts thyroid hormone-dependent SERCA2 gene transcription. Circulation Research 2008;103(5):493-501.

Peter I, Kelley-Hedgepeth A, Fox CS, Cupples LA, Huggins GS, Housman DE, Karas RH, Mendelsohn ME, Levy D, Murabito JM. Variation in estrogen-related genes associated with cardiovascular phenotypes and circulating estradiol, testosterone, and dehydroepiandrosterone sulfate levels. Journal of Clinical Endocrinology & Metabolism 2008;93(7):2779-2785.

Kelley-Hedgepeth A, Peter I, Kip KE, Montefusco MC, Kogan S, Cox D, Ordovas JM, Levy D, Reis SE, Mendelsohn ME, Housman D, Huggins GS. The protective effect of KCNMB1 E65K against hypertension is restricted to blood pressure treatment with ß-blockade. Journal of Human Hypertension 2008;22(7):512-515.

Wong JY, Huggins GS, Debidda M, Munshi NC, De Vivo I. Dichloroacetate induces apoptosis in endometrial cancer cells. Gynecologic Oncology 2008;109(3):394-402.

Huggins GS, Lepore JJ, Greytak S, Patten RD, McNamee R, Aronovitz MJ, Wang P, Reed GL. The CREB leucine zipper regulates CREB phosphorylation, cardiomyopathy, and lethality in a transgenic model of heart failure. American Journal of Physiology - Heart and Circulatory Physiology 2007;293(3):H1877-H1882.

Peter I, Huggins GS, Shearman AM, Pollak A, Schmid CH, Cupples, Demissie S, Patten RD, Karas RH, Housman DE, Mendelsohn ME, Vasan RS, Benjamin EJ. Age-related changes in echocardiographic measurements: association with variation in the estrogen receptor-α gene. Hypertension 2007;49(5):1000-1006.

Huggins GS Wang JY, Hankinson SE, De Vivo I. GATA5 activation of the progesterone receptor gene promoter in breast cancer cells is influenced by the +331G/A polymorphism. Cancer Research 2006;66(3):1384-1390.

Huggins GS, Gewirte H. Chronic stable angina: Clinical presentation and diagnostic techniques. In: Atherothrombosis and Coronary Artery Disease, 2005;Fuster V, Topol EJ, Nabel,Chapter 88:1301-1312.

Huggins GS, O'Gara PT. Clinical presentation and diagnostic evaluation of ST-segment elevation myocardial infarction. In: Atherothrombosis and Coronary Artery Disease, 2005;Fuster V, Topol EJ, Nabel,Chapter 50:849-866.

Michael A, Haq S, Chen X, Hsich E, Cui L, Walters B, Shao Z, Bhattacharya K, Kilter H, Huggins G, Andreucci M, Periasamy M, Solomon RN, Liao R, Patten R, Molkentin JD, Force T. Glycogen synthase kinase-3ß regulates normal post-natal cardiac growth, calcium homeostasis and diastolic function of the heart. Journal of Biological Chemistry 2004;279(20):21383-21393.

Aikawa R, Huggins GS, Snyder RO. Cardiomyocyte-specific gene expression following recombinant adeno-associated viral vector transduction. Journal of Biological Chemistry 2002;277(21):18979-18985.

Huggins GS, Bacani CJ, Boltax J, Aikawa R, Leiden JM. FOG-2 Represses COUP-TF2-Dependent Synergistic Activation of the Atrial Natriuretic Factor Promoter By GATA4. J Biol Chem 2001;276:28029-28036.

Aikawa R, Huggins G.S., Snyder R.O. ; Cardiomyocyte-specific gene expression following recombinant adeno-associated viral vector transduction. J Biol Chem. 2002;277:18979-18985.


Dr. Huggins graduated from Boston University and Pritzker School of Medicine, University of Chicago. He completed his Internal Medicine residency and Clinical Cardiology Fellowship at the Massachusetts General Hospital, Harvard University. Prior to coming to the MCRI, he spent 4 years at The Massachusetts General Hospital in the Cardiology Division. Drs Edgar Haber, Mu-En Lee and Jeffrey Leiden trained Dr. Huggins in molecular biology at the Cardiovascular Biology Laboratory in the Harvard School of Public Health. Currently, he is the Director of the Laboratory of Cardiovascular Genetics of the MCRI and is an Associate Professor of Medicine at Tufts University School of Medicine.