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Giannoula Lakka Klement, MD accepting new patients


Programs + Specialties
Training + Education McMaster University, Hamilton, Ontario, Canada; University of Toronto, Hospital for Sick Children; Harvard University; Dana Farber Cancer Institute
Board Certifications Pediatrics
NPI # 1174579718
Gender Female
Language(s) Greek, Czech

Locations + Directions

Floating Hospital for Children
Floating Hospital, 2nd Floor
800 Washington St.
Box 14
Boston, MA 02111
Fax #: 617-636-7738
Phone #: 617-636-5535

Honors + Awards

2010-2014, RO1, NIH, National Cancer Institute of General Medical Sciences
1997-2001, Terry Fox Fellowship in Cancer Research, National Cancer Institute of Canada
1991, Tisdale Award for Excellence in Research, University of Toronto

Publications + National Presentations

1. Kareva I, Abou-Slaybi A, Dodd O, Dashevsky O, Klement GL (2016) Normal Wound Healing and Tumor Angiogenesis as a Game of Competitive Inhibition. PLoS ONE 11(12): e0166655. doi:10.1371/journal.pone.0166655.

2. Rietman EA, Scott JG., Tuszynski JA, Lakka Klement G. Personalized Anticancer Therapy Selection using Molecular Landscape Topology and Thermodynamics, Oncotarget, October 2016, DOI: 10.18632/oncotarget.12932.

3. Fassel HL,Tracy D, Louer K, Lakka Klement G. Insulin-like Growth Factor 1 Receptor (IGF1R) Inhibition as Maintenance Therapy for Metastatic Ewing Sarcoma, Journal of Pediatric Hematology Oncology, J Pediatr Hematol Oncol. 2016 Oct;38(7):563-9. doi: 10.1097/MPH.0000000000000616.

4. Lakka Klement G, Arkun K, Valik D, Roffidal C, Hashemi A, Klement C, Carmassi P, Rietman E, Slaby O, Mazanek P, Mudry P, Kovacs G, Kiss C, Norga K, Kostadinov D, André N, Slavc I, van Den Berg H, Kolenova A, Kren L, Tuma J, Skotakova J, Sterba J. Future paradigms for precision oncology, Oncotarget, May 2016, DOI: 10.18632/oncotarget.9488.

5. Rietman EA, Platig J, Tuszynski JA, Lakka Klement G. Thermodynamic measures of cancer: Gibbs free energy and entropy of protein–protein interactions. J Biol Phys, Epub March 24th, 2016, DOI 10.1007/s10867-016-9410-y.

6. Lakka Klement G. Eco-evolution of cancer resistance. Sci. Transl. Med. 8, 327fs5 (2016). DOI: 10.1126/scitranslmed.aaf3802.

7. Rössler J, Saueressig U, Kayser G, von Winterfeld M, Lakka Klement G. Treatment of Gorham Stout Disease with a combination of sunitinib and taxol. J Pediatr Hematol Oncol 2015; 37 (8), e481.

8. Benzekry S., Tuszynski JA, Rietman EA, Lakka Klement G. Design principles for cancer therapy guided by changes in complexity of protein-protein interaction networks. Biol Direct. 2015; 10: 32. Published online 2015 May 28. doi: 10.1186/s13062-015-0058-5, PMCID: PMC4445818.

9. Afranie-Sakyi JA, Klement GL. The toxicity of anti-VEGF agents when coupled with standard chemotherapeutics. Cancer Lett. 2015 Feb 1;357(1):1-7. PubMed PMID: 25449430. Epub 2014/12/03. Eng.

10. Kareva I, Waxman DJ, Lakka Klement G. Metronomic chemotherapy: An attractive alternative to maximum tolerated dose therapy that can activate anti-tumor immunity and minimize therapeutic resistance. Cancer Lett. 2014 Dec 23. PubMed PMID: 25541061. Epub 2014/12/30. Eng.

View all of Dr. Klement’s publications on PubMed.


Giannoula Lakka Klement, MD, specializes in the treatment of rare tumors and vascular anomalies, and conducts basic science research into tumor and wound angiogenesis, with emphasis on the role of platelets in angiogenesis. A Pediatric Hematologist/Oncologist at Floating Hospital for Children at Tufts Medical Center, she is also the Director of Rare Tumors and Vascular Anomalies Center at Floating Hospital and the Co-director of the Precision Medicine Program at Tufts Cancer Center and Pediatric Neuro-oncology. Dr. Klement is an associate professor at Tufts University School of Medicine.