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Cheleste M. Thorpe, MD


Overview

Programs + Specialties
Research Interests Gut immune activation, host-pathogen interactions and probiotics
Training + Education Tufts University School of Medicine; Tufts Medical Center
Board Certifications Infectious Disease
NPI # 1356385850
Gender Female

Locations + Directions

Tufts Medical Center
800 Washington St., #41
Boston, MA 02111
Fax #: 617-636-5292,
Phone #: Lab: 617-636-8419

Honors + Awards

2009-2010, Outstanding Tufts University School of Medicine Lecturer
2007, Teaching Excellence Award from Geographic Medicine and Infectious Disease Fellows
2000, Oliver Smith Award (recognizes excellence, compassion and service in patient care), Tufts Medical Center
2000, Natalie V. Zucker Research Center for Women Scholars Award
1999, Oliver Smith AWard, Tufts Medical Center
1999, Maxwell Finland Young Investigator Award of the Massachusetts Infectious Diseases Society
1993, American Medical Women's Association Achievement Citation
1993, Hewlett-Packard Award, Tufts University School of Medicine
1993, Class of 1928 Award for Outstanding Work in Anatomy, Tufts University School of Medicine
1993, William Dameshek Internal Medicine Award, Tufts University School of Medicine
1992, Alpha Omega Alpha Honor Society, Tufts University School of Medicine
1982-1985, Class Honors, University of Michigan
1983, Branstrom Award, University of Michigan
1983, Freshman Scholar, University of Michigan

Publications + National Presentations

1. Paton, A.W., Beddoe T., Thorpe C.M., Whisstock J.C., Wilce M. C. J., Rossjohn J., Talbot U.M., and Paton, J.C. 2006. AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP. 443:548-52.

2. Khaitan, A., Ritchie J.M., Paton A.W., Jandhyala D.M., Thorpe C.M. 2007. The Operon Encoding SubAB a Novel Cytotoxin is Present in US STEC Isolates. J. Clin Micro 45:1374-5.

3. Chong, D.C., Paton, J.C., Thorpe, C.M., and Paton, A.W. 2008. Intracellular trafficking of subtilase cytotoxin, a novel AB5 bacterial toxin that targets the endoplasmic reticulum chaperone BiP. Cellular Microbiology Mar;10 (3):795-806.

4. Jandhyala, D.M., Ahluwalia A., Obrig T., and Thorpe C.M. 2008. ZAK: a MAP3Kinase that transduces Shiga toxin and ricin induced proinflammatory cytokine expression. Cellular Microbiology, Jul;10 (7):1468-77.

5. Wolfson J.J., May K.L., Thorpe C.M., Jandhyala D.M., Paton J.C., Paton A.W. Subtilase cytotoxin activates PERK, IRE1, and ATF6 endoplasmic reticulum stress-signaling pathways. 2008. Cellular Microbiology, 2008 Sep;10 (9):1775-86. PMCID: PMC2575110

6. Wolfson, J.J., Jandhyala D.M., Gorczyca L.A., Qadeer Z., Manning S.D., Hadler J., Rudrik J.T., Thorpe C.M. 2009. Prevalence of the operon encoding Subtilase Cytotoxin in non-O157 STEC isolated from humans in the United States. J. Clin. Micro. 47:3058-3059.

7. Rajendran P., Rajan D.P., Kang G., Thorpe C. Shiga toxin-producing Escherichia coli infection in South India. J Med Microbiol. Nov 2009; 58: 1525 -1526.

8. Jandhyala, D.M., Rogers, T.J., Kane, A., Paton, A.W., Paton, J.C., and Thorpe, C.M. 2010. Shiga Toxin 2 and Flagellin from Shiga-Toxigenic Escherichia coli Superinduce Interleukin-8 through Synergistic Effects on Host Stress-Activated Protein Kinase Activation. Infection and Immunity 78:2984-2994.

9. Wang H., Paton JC, Thorpe CM, Bonder CS, Su WY, Paton AW. 2010. Tissue factor-dependent procoagulant activity of subtilase cytotoxin, a potent AB5 toxin produced by Shiga-toxigenic Escherichia coli. J. Infect. Dis 1;202:1415-23.