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FACULTY RESEARCH AT THE FLOATING
Numerous Floating Hospital faculty members currently have major NIH funding as principal investigators on a range of child health and basic research projects. One of our major achievements was establishing the MOTHER INFANT RESEARCH NSTITUTE (MIRI), led by Floating Hospital’s Vice Chair for Research and Academic Affairs Diana Bianchi, MD. It is the only research institute in the United States that combines pediatrics and obstetrics to investigate the events that occur during pregnancy
and their impact on trans generational health.
Floating Hospital’s Division of Clinical Research, headed by Olaf Dammann, MD, is focused on clinical trials and network-based observational studies on a range of pediatric health issues. Through the division’s efforts, Floating Hospital was recently named one of only 17 centers worldwide — and the only one in the United States — to be part of an international randomized clinical trial, funded by the European Union, comparing treatments and outcomes for neonatal shock.
In addition, Hematologist/Oncologist Giannoula Klement, MD, renowned for her work in angiogenesis, received a grant from the US-Israel Binational Science Foundation in addition to an R01 grant from the NIH; and H. Cody Meissner, MD, Chief, Division of Pediatric Infectious Diseases, has received Pfizer support for a clinical trial on treating aspergillosis.
Altogether, Floating Hospital physician scientists published more than 70 original articles in major peer-reviewed medical journals in the past year, advancing important new discoveries as well as enhancing our institution’s reputation and visibility around the world.
More information on Research at the Floating
RESIDENT RESEARCH AND SCHOLARLY ACTIVITIES
In the Pediatric Residency Program at Floating Hospital for Children, there is a scholarly project requirement for all residents. The pediatric residency programs’ research mission is to engage residents in longitudinal projects through which research methodology, quality improvement methods and educational scholarship can be taught and significant results can be shared with peers and mentors
The curricular goal of this project and the academic block rotations is to ensure that all residents have participated in the process of scientific discovery and inquiry based on a scientific question of their interest. The resident will develop skills which will allow them to participate in a longitudinal scholarly project which may be based in basic science, clinical, educational or health services research.
All of the residents at our program will also become trained in quality improvement methods and will participate in a second longitudinal project demonstrating the process of QI. Mini workshops on Quality Improvement methods are given by skilled faculty and each resident presents a systems improvement conference which focuses on identifying and improving systems errors that occurred at the Floating.
RESIDENT SCHOLARLY PROJECT TITLES
Adolescent Inpatient Pregnancy Screening Study
Documentation Of Discharge Criteria And Counseling In A Chart Review Of Infants Admitted With Respiratory Distress In An Intensive Care Setting.
Evaluation Of A New Bilirubin Screening Protocol And The Transcutaneous Bilirubinometer In The Newborn Nursery.
Gender-Dependent Association of the Toll-like Receptor 8 A1G Polymorphism with Advanced Inflammation and Fibrosis in Chronic HCV Infection
TLR8 Stimulation Up-Regulates Heat Shock Protein 90 In Human Neonatal Monocytes And Monocyte-Derived Dendritic Cells
Talking To Children About Dwarfism; A Close Look At Parental Experience With Syndrome Disclosure
Marked Improvement And Defervescence Of Persistent Fever After One Course Of Intravenous Immunoglobulin In A Patient With Bacterial Infective Endocarditis.
Experience of Lubiprostone in Use in Children with Refractory Constipation and Dysmotility
Brazilian Medication Project – Pediatrician Education Arm
Case Report Of Acetaminophen Overdose In A Fetus Treated With N-Acetylcysteine In Utero And Ex Utero.
Case Report of Oral Lichen Planus in an Adolescent
Assessment of Social-Emotional Needs of Young Children in Child Welfare
RECENTLY GRADUATED RESIDENT PUBLICATIONS AND POSTERS DURING RESIDENCY
Bechard, Guinan E, Feldman H, Tang V, Duggan C; Prognostic factors in the resumption of oral dietary intake after allogeneic hematopoietic stem cell transplantation (HSCT) in children. Journal of Parenteral and Enteral Nutrition. July/August Vol 31 (4): 295-301, 2008.
Ferwerda B, Alonso S, Banahan K, McCall MBB, Giamarellos-Bourboulis EJ, Ramakers BP, Mouktaroudi M, Fain PR, Izagirre N, Syafruddin D, Cristea T, Mockenhaupt FP, Troye-Blomberg M, Kumpf O, Maiga B, Dolo A, Doumbo O, Sundaresan S, Bedu-Addo G, van Crevel R, Hamann L, Oh DY, Schumann RR, Joosten LA, de la Rúa C, Sauerwein R, Drenth JP, Kullberg BJ, van der Ven AJ, Hill AV, Pickkers P, van der Meer JW, O'Neill LA, Netea MG. Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock 2. PNAS 2009; 106(25): 10272-10277. PMID: 19509334
Grozavescu CE, Chang AD, Hyde J, Leslie LK. Assessment of Social-Emotional Needs of Young Children in Child Welfare. Poster presetned at Pediatric Academic Society annual meeting, Vancouver, BC, May 2010.
Grozavescu CE, Kamath S, Garg A. Urine Evaluation in Crying, Afebrile Infants: Does the Study's Data Support This Recommendation? E-Letter, Pediatrics, May 2010.
Kaplan E, Min JY, Ke Q, Chen Y, Niethammer M, Rana JS, Malek S, Verheugt FW, Morgan JP. Calcium and cyclic nucleotides affect TNF-alpha-induced stem cell migration. Biochem Biophys Res Commun. 2009 May 1;382(2):241-6. Epub 2009 Feb 20.
Llosa N, Grozavescu CE. A teen with persistent painful papules and plaques. Contemporary Pediatrics, Sept. 1, 2009.
Oh DY, Taube S, Hamouda O, Kücherer C, Poggensee G, Jessen H, Eckert JK, Neumann K, Storek A, Pouliot M, Borgeat P, Oh N, Schreier E, Pruss A, Hattermann K, Schumann RR; A functional toll-like receptor 8 varient is associated with HIV disease restriction. Journal of Infectious Diseases. 2008;198(5): 701-9.
Oh DY, Jessen H, Kücherer C, Oh N, Poggensee G, Bartmeyer B, Jessen A, Pruss A, Schumann RR, Hamouda O; CCR5Δ32 genotypes in a German HIV-1 seroconverter cohort and report of HIV-1 infection in a CCR5Δ32 homozygous individual. PLoS ONE. 2008; 3(7): e2747.
Oh DY, Baumann K, Hamouda O, Eckert JK, Neumann K, Kücherer C, Bartmeyer B, Poggensee G, Oh N, Pruss A, Jessen H, Schumann RR; A frequent functional toll-like receptor 7 polymorphism is associated with accelerated HIV-1 disease progression. AIDS. 2009; 28;23(3): 297-307.
Oh DY, Schumann RR, Hamann L, Neumann K, Worm M., Heine G. Association of the toll-like receptor 2 A-16934T promoter polymorphism with severe atopic dermatitis. Allergy 2009; 64(11):1608-15. PMID: 19627277
leickhardt E, Celandine A, Dammann C, Dammann O. Single Neucleotide Polymorphisms (SNPs), Gestational Age, and Levels of Interleukin (IL) 6, IL10 and Neuregulin-1[beta] (NRG) in Umbilical Cord Blood. Poster at PAS, 2009, and Early Human Development, 2010.
Storek A, Landt O, Fleischer C, Baumann K, Lass U, Schumann RR,
Oh DY. Quadruplex Genotyping of TLR-8 Polymorphisms in a Single Reaction. Analytical Letters 2010; 43(6): 1066-1074. Epub 2010 March 11.
Tang V, Walker T, Saslowsky T, Boone J, Rufo P; Fecal ASCA measurements in the assessment of pediatric patients with known or suspected Crohn’s disease. Manuscript in Preparation.
Tang V, Sunku B, Flores A. Experience of lubiprostone use in children with refractory constipation and colonic dysmotility. Poster Presentation. NASPGHAN Annual Meeting and Postgraduate Course: National Harbor, MD. November, 2009.
Wang JF, Min JY, Hampton TG, Amende I, Yan X, Malek S, Abelmann WH, Green AI, Zeind J, Morgan JP. Clozapine-induced myocarditis: role of catecholamines in a murine model. Eur J Pharmacol. 2008 Sep11;592(1-3):123-7. Epub 2008 Jun 29.
Zandman S, Cowper R, Madan J, Maron J. Physician Administration of Prophylactic Indomethacin in Premature Neonates. Manuscript in process.
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